![]() During inspiration, contraction of the diaphragm creates negative pressure around the lungs allowing the lungs to expand in addition to the positive pressure exerted on the lungs from the airways. ![]() Īnother important part of lung physiology is compliance which simply means the opposite of stiffness. CO 2 diffuses more readily than O 2 because of its high plasma solubility. The barrier to this process includes a cytoplasmic extension of type 1 cells, the basement membrane, and the capillary endothelial layer. This difference results in the diffusion of O 2 from the alveolus to the capillaries. ![]() Gas exchange between the alveolus and the blood capillary depends on the passive diffusion of PO 2 in the alveolus (around 100 mmHg), and the blood entering the capillary (around 40 mm).
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